B cepacia is an organism of low virulence and is a frequent colonizer of fluids used in the hospital (eg, irrigation solutions, intravenous fluids). Burkholderia cepacia is a very common bacterium that can cause serious respiratory tract infections.
Infections dominated by organisms of the Burkholderia cepacia complex, a group of at least 18 closely-related species of gram-negative bacteria, are particularly difficult to treat. Burkholderia multivorans is an opportunistic pathogen capable of causing severe disease in patients with cystic fibrosis (CF). Burkholderia is a genus of Proteobacteria whose pathogenic members include the Burkholderia cepacia complex which attacks humans and Burkholderia mallei, responsible for glanders, a disease that occurs mostly in horses and related animals; Burkholderia pseudomallei, causative agent of melioidosis; and Burkholderia cepacia, an important pathogen of pulmonary infections in people with … B. cepacia bacteria are often resistant to common antibiotics. Effective strategies to manage Burkholderia cepacia complex (Bcc) infections in cystic fibrosis (CF) patients are lacking. Burkholderia multivorans is a member of the Burkholderia cepacia complex (Bcc), a group of closely related Gram-negative bacterial species that are inherently resistant to many antibiotics.
The authors have concluded that there was an extreme lack of evidence in this area of treatment management for people with cystic fibrosis. The pathogen is resistant to a broad range of antibiotics, and infections can cause severe disease and poor prognosis in patients. Burkholderia cepacia, a bacteria which used to be called Pseudomonas cepacia, is a rare but significant threat to people living with cystic fibrosis (CF).While the infection is most often symptom-free, it can turn serious, and even life-threatening.
She had sputum colonisation by Pseudomonas aeruginosa and Staphylococcus aureus and since 2006, she also had Burkholderia cepacia in sputum, which was typed as genomovar II ( Burkholderia multivorans ). B. cepacia poses little medical risk to healthy people. Burkholderia multivorans is an opportunistic pathogen capable of causing severe disease in patients with cystic fibrosis (CF). Patients may be chronically infected for years, during which the bacterial population evolves in response to unknown forces. Burkholderia cepacia [burk-hōld–er–ee-uh si–pay–shee–uh] (also called B. cepacia) is the name for a group or “complex” of bacteria that can be found in soil and water. Introduction. These infections may be associated with a fulminant necrotising pneumonia. 1. Prior sputa had shown chronic colonization for >10 years with B. multivorans (genovar II) as the predominant pathogen (cultured from all 10 sputum specimens over the prior 12 months), with Pseudomonas aeruginosa identified in 50% of specimens. Burkholderia multivorans poses a serious health threat to Cystic Fibrosis patients due to innate resistance to multiple antibiotics and acquisition of resistance to a range of antibiotics due to the frequent use of antibiotics to treat chronic infections. The CDC and FDA have joined forces with various state and local health departments and health care facilities to investigate a multistate outbreak of Burkholderia cepacia infections. When a doctor or nurse gets a throat or sputum culture from a person with CF, the laboratory tests the culture in a specific way to help find any B. cepacia complex species.