In this review, we will focus on recent advances in the field of NK cell immunotherapy, … R EVIEW Chimeric antigen receptor (CAR)-modiﬁed natural killer cell-based immunotherapy and immunological synapse formation in cancer and HIV Dongfang Liu1,2&, Shuo Tian 1, Kai Zhang , Wei Xiong , Ndongala Michel Lubaki1, Zhiying Chen1, Weidong Han3& 1 Center for Inﬂammation and Epigenetics, Houston Methodist Research Institute, Houston, TX 77030, USA 2 Department of … Seeallarticles inthis CCRFocus section, "Opportunities and Challenges in Cancer Immunotherapy." The details of the safety profile and the antitumor responses were also disclosed. Natural killer (NK) cells, potent cytotoxic effectors, also hold potential to be effectively harnessed for immunotherapy. Citation: Mehta RS and Rezvani K (2018) Chimeric Antigen Receptor Expressing Natural Killer Cells for the Immunotherapy of Cancer. Clin Cancer Res; 22(8); 1845–55. et al.
NK cells are components of the innate immune system that act as key regulators and exhibit a potent tumor c … With the development of technologies that can transform immune cells into therapeutic modalities, immunotherapy has remarkably changed the current paradigm of cancer … Novel immunological results including the increased peripheral blood Vα24 NKT cells and IFN‐producing cells after the immunotherapy were revealed. Immunotherapy for cancer has made some of its biggest inroads against hematologic malignancies such as leukemia and lymphoma, with treatments such as checkpoint inhibitors and CAR T-cell therapies producing long-lasting remissions in some patients. An immunotherapy approach that uses a new method of preparing immune cells may provide a potential treatment option for some patients with acute myeloid leukemia (AML), results from an early-stage clinical trial suggest..
Here, we review recent data on NK cell recognition of melanoma at various stages of the disease and propose a combinatorial strategy to exploit fully the potential of NK cells. ABSTRACT Unprecedented clinical success has recently been achieved in cancer immunotherapy using cytotoxic T cells armed with activating tumor-specific Chimeric Antigen Receptors (CARs). Natural killer cells: a historical background. Clin Cancer Res; 22(8); 1845–55. A growing number of scientific reports and clinical studies have shown promising anti-tumor effects when using NK cell-based immunotherapy. Natural killer (NK) cells are innate immune cells endowed with potent cytolytic activity against tumors, and meanwhile act as regulatory cells for the immune system. Natural killer (NK) cells have emerged as a potent alternative immunotherapeutic approach to T cell therapy for cancer. Recent progress in our understanding of NK cell immunobiology has paved the way for novel NK cell-based therapeutic strategies for the treatment of cancer. Natural killer (NK) cells have potential as a cellular anticancer therapy that could be significantly safer, cheaper, and faster, researchers say. Natural killer (NK) cells are innate immune cells endowed with potent cytolytic activity against tumors, and meanwhile act as regulatory cells for the immune system. Natural killer cells (NKs) and tumor infiltrating lymphocytes (TILs) can also be enhanced and reinfused in patients. A better understanding of the complex interactions between the immune system and tumour cells from different origins has opened the possibility to design novel procedures of antitumoral immunotherapy. Carrega, P. et al. Cancer immunotherapy has been firmly established as a new milestone for cancer therapy, with the development of multiple immune cells as therapeutic tools. Introduction CD8 T lymphocytes, natural killer cells, and certain CD4 T-helper lymphocytesare the onlycell types in the organism that ©2016 AACR . 93. Current approaches in immunotherapy include the relatively basic administration of cytokines, vaccines (Melero et al., 2014) and antibodies (Michaud et al., 2014) as well as more advanced manipulations involving in vitro expansion and infusion of specific T cell (Restifo et al., 2012) and natural killer (NK) cell subsets (Vivier et al., 2012). Although NK cells can discriminate between “self” and “non-self,” recognize abnormal cells, and eliminate transformed cells and malignancies in real time, tumors develop several strategies to escape from NK cell attack. Front. Natural killer cells are innate immune lymphocytes that play anti‐tumour and anti‐viral functions, either through direct cytotoxic activity or production of effector cytokines. Personalized immunotherapy based on individual genetic, molecular, and immune profiling is a potentially achievable future goal. Cell-based immunotherapy targets under evaluation in prostate cancer clinical trials include: The anti-tumor efficacy of NK cell therapies has been limited by a … Currently, various approaches are being used to enhance the number and function of NK cells.